International Seminar Gala-Merck

MERCK and GALA’s team of experts are pleased to welcome you to the Seminar on How to accelerate your pharmaceutical developments based on the solid dispersion strategy.

26 septembre 2019

Seminar How to accelerate your pharmaceutical developments
based on the solid dispersion strategy

September 26th 2019

organised by MERCK and GALA Platform

Castres, FRANCE

PROGRAMME

 

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gala.png, par csuderie

MERCK and GALA’s team of experts are pleased to welcome you to the Seminar on How to accelerate your pharmaceutical developments based on the solid dispersion strategy. Join us at Gala® platform on September 26th 2019 to share scientific expertise, knowledge and successful approaches to lead solid dispersions projects.

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capture_decran_2019-06-27_a_15.36.48.png, par csuderie

The solubility of drugs is one the most challenging aspects in developing formulations for novel drug discovery. Pharmaceutical solid dispersion is a powerful strategy enhancing the solubility and bioavailability of water poorly-soluble drugs. Some powerful strategies can be adopted to ease the whole development process, from the early phase screening to the manufacturing process design, process design, thus accelerating and simplifying your drug formulation. As different manufacturing processes may originate products with properties the adequate selection of the manufacturing process is also crucial for the success of the product. Solvent-free processing and versatility are the most attractive attributes of the HME technology, which will be highlighted in the frame of this meeting.

The Seminar will be a one-day event divided in two parts:
4 lectures in the morning; 2 parallel demo/work sessions (Hot Melt Extrusion and Raman microscopy)
followed by the visit of Gala platform facilities in afternoon.

 

Experts speakers from industry (Merck, KGaA, Evotec Toulouse, Witec Corporation, Zeiss Group) and academy (University of Auvergne, France) will be present.

Focused on following topics :

  • Selecting the appropriate solid form in drug discovery phase to improve oral bioavailability and/or developability of compounds.
  • Polyvinyl-alcohol a powerful excipient to stabilize amorphous solid dispersions using hot melt extrusion.
  • Evaluation of in vitro dissolution techniques for supersaturating drug delivery systems
  • Presentation of the principle and applications of correlated SEM (Structural and elemental characterization) and Confocal Raman Microscopy (Chemical identification and imaging) in the pre-formulation and reverse engineering.
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